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As the toxin is transported by way of the Golgi and ER, it's additional processed and activated. Vesicles that go to late endosomes (ultimately lysosomes) from the Golgi or the plasma membrane are clathrin-coated. CHAPTER 10 / RELATIONSHIP BETWEEN CELL BIOLOGY AND BIOCHEMISTRY 177 Vesicles launched from the trans face of the Golgi advanced journey to endosomes as clathrin-coated vesicles. The hormone Exocytotic vesicles release proteins into the extracellular space after fusion insulin is synthesized as a prohor- of the vesicular and plasma cell membranes. Clathrin Trans-Golgi Medial-Golgi COPI Cis-Golgi COPI COPII ER-golgi Fusion intermediate of COPII compartment vesicles Rough ER Fig. COP II vesicles (coatomer- coated) form within the tough ER and move to the Golgi. COP I vesicles typically go from the trans to the cis Golgi to the ER. ADP-ribosylating factor), and COP II vesicles contain the monomeric G protein Sar (one other member of the Arf household). SNARE) on the target membrane, thus guaranteeing that COP I vesicles.
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